glutathione and coronavirus Pandemic Update 70: Deficiency, Oxidative Stress, COVID 19 The Role of Glutathione in

& Shimomura, Y

Oxidative stress leads to the buildup of reactive oxygen species (ROS) in cells, resulting in damage of cell structure and function

Silymarin shows various biological activities in scientific investigations that are currently being further researched: Antioxidant: Protects cells against oxidative stress caused by free radicals Hepatoprotective: Under experimental conditions, silymarin can inhibit the binding of certain liver toxins to liver cells and support the regenerative capacity of hepatocytes Anti-inflammatory: Anti-inflammatory properties demonstrated in cell models Cholagogue: Possible support for bile production and bile flow Lipid profile: Influence on cholesterol and fat metabolism parameters in clinical studies Immunomodulatory: Activity in the immune system demonstrated in animal models Milk Thistle and the Liver Supporting liver health is the most thoroughly researched area of application for milk thistle extract

The temporal response of potential translation biomarkers of liver injury such as acyl carnitines, miR-122 and proteins described in this review are dependent on toxicokinetics of APAP in each species