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Previously, a study based on proteomic analysis had revealed marked transcriptional repression of other Nrf2-induced antioxidant proteins including CK2, ERK1/2, PKC, GPx, Mgst1, peroxiredoxin 3 (Prdx3), in both preclinical models and in human spinal MNs from ALS patients [253]

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Total phenolic content and antioxidant activities of pomegranate juice and whey based novel beverage fermented by kefir grains

Based on existing research, we hypothesize that lactylation modifications have a time-specific impact on the activation state of microglia, similar to the lactate concentration sensing effect observed in AD