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Interestingly and paradoxically, a low PKM2 activity is also related with an increased pyruvate conversion into lactate, through the action of lactate dehydrogenase A, at the expense of NADH which is oxidized to NAD +

A phase 1b dose escalation trial of SAR650984 (anti-CD38 mAb) in combination with lenalidomide and dexamethasone in relapsed/refractory multiple myeloma

Treatment for all forms of glaucoma is limited to pharmacological lowering of IOP (the sole treatable risk factor) and, in rare cases, anterior eye surgery and laser photo/thermocoagulation but there are no treatments for neuronal degeneration (reviewed in (13-15))