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Among the key genes implicated in this process are tyrosinase (TYR), tyrosinaserelated protein 1 (TYRP1), tyrosinaserelated protein 2 (TYRP2), microphthalmiaassociated transcription factor (MITF), paired box gene 3 (Pax3), SRYbox transcription factor 10 (Sox10), melanocortin 1 receptor (MC1R), tyrosine kinase receptor (cKit), Plexin C1 (Plexin C1), MelanA (MelanA), premelanosome protein (Pmel17), and the receptor for hepatocyte growth factor (MET)

What is widely sold online as BPC-157 powder or BPC-157 nasal spray is typically labeled for research use only and is explicitly not intended for human use

The research use only designation ensures our peptide therapy compounds remain available for legitimate scientific research while complying with research chemical regulations

The shRNA sequences (Supplementary Table 1) were synthesized by Genewiz (Tianjin, China) and inserted into pLKO.1-TRC vector (Addgene #10879)