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However, the restricted sample size, the lack of validated endpoint measurements, and the absence of intermediate time points significantly limit the outcomes of the study

Many researchers attribute this to tolerance when the real culprit is a degraded vial

The absolute bioavailability (%F) is calculated as a percentage of the area under the drug concentration curve (AUC) of the whole body or blood in the area under the curve (AUC) of IV administration adjusted to the amount of drug provided through this route of administration