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Using complementary mouse and pig infection models, along with in vitro macrophage and neutrophil assays, they revealed how hvKp subverts innate immune defenses in the liver and resists Kupffer cell-mediated clearance, explaining the strong hepatic tropism of hypervirulent K1 and K2 strains

4) Also, it was found that the treatment with NO-Cbl in dogs is a viable anti-cancer therapy that capitalizes on the tumor-specific properties of the vitamin B12 receptor

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