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White PD, Goldsmithb KA, Johnson AL, et al

Abstract To develop an LCMS/MS method for simultaneous quantification of mildronate and L-carnitine, and to investigate the pharmacokinetic profile of mildronate in rats, its effect on L-carnitine homeostasis, as well as the exposure characteristics, underlying mechanisms, and their associations with therapeutic efficacy and toxicity risks

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Increasing clinical trials are investigating the use of probiotics in the treatment of Parkinson's disease, with more evidence showing that probiotic supplementation can improve symptoms, particularly constipation, in patients with Parkinson's disease, providing a basis for future clinical treatments [166]