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doi: 10.1097/wnr.0000000000000071 52 ZhangWXieYWangTBiJLiHZhangLiQet al

J Cell Sci 111:18531865

patients can resume normal activities immediately

However, recent studies have demonstrated that serum melatonin levels are positively associated with oxidative stress, IL-6 level, SOFA score and mortality in severe septic patients, and non-survivors showed higher serum melatonin [64, 65]