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10.1146/annurev-pharmtox-010510-100505 74 LiM.TangX.LiuX.CuiX.LianM.ZhaoM.et al (2020)

6.2.3 Reproductive effects on birds DDT, or more specifically its metabolite DDE, causes the shells of birds' eggs to be thinner than normal

Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD4-selective WNT surrogate in mice

Based on this finding, the primary hematoma caused by the rupture of the blood vessel is likely to destroy the BBB by causing pyroptosis in the endothelium, forming a positive feedback loop that further exacerbates hemorrhage and secondary brain injury (7, 105)