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Combination anti-CTLA-4 plus anti-PD-1 checkpoint blockade utilizes cellular mechanisms partially distinct from monotherapies

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Ohno et al., 2021) in astrocytes revealed that the dysfunction of the BBB initiates hyperactivation of transforming growth factor beta (TGFB/TGF-) signaling, which is vital to elicit neuronal dysfunction and age-related neuropathology (Senatorov et al., 2019

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