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The results were in accordance with those of many prospective studies, which demonstrated a strong relationship between the GGT activity and the incidence of ALD [1820]

Specifically, IRPs binding to IREs at the 5-UTR suppress translation of ferritin, FPN1, and amyloid precursor protein (APP), while IRP binding at the 3-UTR stabilizes mRNAs of TfR1 and DMT1, thereby promoting iron uptake under conditions of deficiency (Mai et al., 2023)