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DPP4, a potential tumor biomarker, and tumor therapeutic target

Neither acts through a hormonal axis, so the stack is studied as a repair-signalling pair rather than a growth-hormone approach

human lifespan trials do not)6 Optimal dosing windows, cycling duration, and rest intervals for stacked protocols The Frontiers in Aging 2026 review stated the limitation clearly: significant knowledge gaps include optimal dosing regimens, combination therapy effects, and biomarkers for monitoring efficacy.2 This is why supervised clinical protocols with regular lab monitoring and dose titration are not optional

Moreover, in an elderly I/R injury mouse model of CKD, microvascular rarefaction and inflammation are more significant compared to young controls [71]