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From a translational perspective, OSC-mediated immunomodulationprincipally via Nrf2 activation and NF-B suppressionoffers therapeutic benefit in hyperinflammatory states but may compromise host defense if dosing, duration, or clinical context are not carefully controlled (Fagian et al., 2020

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Oral absorption is considered too unreliable in patients with pernicious anemia or other conditions resulting in malabsorption of vitamin B12

Diethylester derivatives were seen to be more easily delivered into cells (Cacciatore et al., 2010)