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demonstrated that the expression of outer membrane proteins from family 5 efflux pumps, including hefa ( HP0605 ), hefd ( HP0971 ), and hefG ( HP1327 ), was significantly greater in biofilm-forming cells than in planktonic cells (Yonezawa et al., 2019)

This heterogeneity complicates the elucidation of pharmacokinetic and pharmacodynamic profiles, particularly in compounded preparations, thereby hindering standardization and clinical validation

PMID: 149 PerinoASchoonjansK

At present, although some studies have shown that inorganic selenium sources, such as sodium selenite (SS), which are mainly used as dietary selenium source additives, have significant detoxification effects on mycotoxins and heavy metal poisoning [4447], they are still limited by acute toxicity, accelerated oxidation, and low bioavailability in the application process