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Each compound, with the exception of 1.65 , showed no cytotoxicity up to 3.25 mmolL 1 , and there was mostly over 100% cell viability on Caco-2, Fibroblast, and HT29-MTX-E12 cells at each tested concentration (as shown in Table 7)

BioAssay Systems GSH/GSSG Assay Kit is designed to accurately measure total, reduced, and oxidized glutathione in biological samples using an enzymatic method that utilizes Ellmans Reagent (DTNB) and glutathione reductase (GR)

A possible mechanism that can lead to oxidation of vicinal thiol groups by reduction of glutathione-bound mercury(II) ions is described in the scheme of Figure 3

Isocitrate lyase (ICL) inhibitors ICL plays a crucial role in mycobacterial glyoxylate and methyl isocitrate cycles, which are essential for M.tb survival, virulence [100], and antibiotic tolerance [101]