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Compend Contin Educ Vet (2012) 34:E14

& Volkow, N

Abstract Liver fibrosis is considered an epidemic health problem since it can lead to several insults that can be fatal

Biguanide-derived neuroprotective agent (metformin) To mitigate neuroinflammation and mitochondrial dysfunction in PD, metformin was encapsulated into PLGA, which were further coated with BV2 microglial cell membranes to enhance the targeting efficiency to neuroinflammatory sites (BV2-metformin-loaded PLGA) for intranasal administration 19