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To restore vitamin B12 levels and also fight vitamin b12 deficiency, administer half of the above doses and repeat at 12-week intervals, if necessary

In the vessel wall, impairment of lipid metabolism could cause pathologic lipids accumulation ( The oxidative imbalance may be inevitably enhanced during the atherosclerotic plaque progression as long as the modified lipoproteins and reinforcements possess proinflammatory properties (Figure 1)

Under hypoxic conditions, L-2-hydroxyglutarate (L-2-HG) was proven to be generated by lactate dehydrogenase A (LDHA) and malate dehydrogenase (MDH) 88,89