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DOI: 10.1038/nrg1655

In the end, six studies were included according to the inclusion and exclusion criteria

Immobilization Affinity tags can immobilize tagged proteins on surface of plasmon resonance chips, ELISA plates

In addition, betaine significantly upregulated the protein expression of AMPK (AMP-activated protein kinase), FGF10 (fibroblast growth factor 10), and ATGL (adipose triglyceride lipase) and suppressed hepatic lipid accumulation in mice, suggesting that betaine prevents NAFLD via FGF10/AMPK signaling pathway ( Betaine supplementation was observed to decrease histopathological alterations and serum markers of hepatotoxicity in animal models of acute and chronic non-alcoholic liver injury