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10.3748/wjg.v20.i48.18070 204

Defective Rac1 protein is associated with increasing activity of the mTOR pathway and subsequent inhibition of autophagy (Matsushita et al

Intravenous treprostinil should be reserved for patients who are intolerant of the subcutaneous route, patients with a preference for intravenous administration, or in whom the risks are considered warranted