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Mechanistically, cancer cells capable of inducing cancer cachexia are secreting IL-6, which subsequently induces autophagy in differentiated muscle cells via IL-6 signaling and therefore might be relevant for the characteristic muscle and weight loss during cancer cachexia (276)

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Therefore, by mechanically removing this microbial load through scaling and root planing, made tolerable for patients via local anesthesia, our intervention is expected to down-regulate local inflammatory pathways, potentially reducing OLP lesion severity and pain