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Discovered in the 1970s, DSIP is found in cerebrospinal fluid (CSF) in the brain and plasma, and its key role lies in modulating sleep patterns

At lower concentrations, they have beneficial effects and indulged in different physiological processes such as redox regulation, mitogenic responses, cellular signaling pathways, and an immune function while at a higher level, these reactive species generate nitrosative and oxidative stress (Phaniendra et al., 2015)

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