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First in vivo demonstration that lentiviral-mediated somatic transduction of oncogenic MET in hepatocytes of adult mice leads to the development of hepatocellular carcinomas

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Due to the prominent physiological function, the Wnt/-catenin signaling must be strictly controlled because its dysregulation, which is caused by different stimuli, may lead to alterations in cell proliferation, apoptosis, and inflammation-associated cancer