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Description

Cell Death Dis 14 , 22 (2023)

OpazoMCCoronado-ArrzolaIVallejosOPMoreno-ReyesRFardellaCMossoLet al

Fluoxetine-induced androgen deficiency may lead to the increased expression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1), which activates the pro-apoptotic factor p53 through deubiquitination and triggers germ cell apoptosis

This vicious cycle accelerates maladaptive remodeling, underscoring the need for therapies that jointly preserve mitochondrial integrity and restore FAO homeostasis