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Despite their potential to ameliorate neurodegeneration through upregulation of NRF2 and its target genes, as shown by numerous pre-clinical studies, their molecular off-target effects and concomitant unpredictable side-effects pose an obstacle for clinical trials and approval

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Hub genes within this module, along with variably expressed transcription factors, provide strong candidates for future validation

3 Mechanisms involved Peritoneal Fibrosis Multiple lines of evidence point to the importance of mechanisms involved in the peritoneal membrane alterations described as EMT of PMCs and generation of myofibroblasts, which play a characteristic role in the subsequent functional deterioration of the peritoneal membrane (Terri et al., 2021