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Age (Dordr) 35:583596 Tulpule K, Dringen R (2012) Formate generated by cellular oxidation of formaldehyde accelerates the glycolytic flux in cultured astrocytes

Itaconate has also been described to modulate immune responses though the activation or suppression of a range of transcriptions factors to limit pro-inflammatory cytokines ( Figure 2B ), induce antioxidant responses and regulate macrophage polarization ( Figure 2C )