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Oxidative stress responses clarified the functioning of central principal switches like nuclear factor (NF)-B (NFB) or the Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor2 (Nrf2)-antioxidant response element (ARE) redox regulator pathway (Sies, 2015

Even short exposures can reduce stability, especially for reconstituted solutions

We also observed that PC cells with upregulating expression of SLC7A11 at the PM level induced by VRK2 display decreased incidence of ferroptosis, which accounts for why PC cells with VRK2 high expression are insensitive to GSH inhibition alone