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10.1016/j.psj.2023.102773 83 LuC

This slower transit may increase gas retention and create the sensation of abdominal fullness (NIH)

Synapse 61 , 96105 (2007)

A third proposed mechanism of action is based upon the observation that polyamines accumulate in the synovium of patients with RA and that metabolism of these polyamines by macrophages leads to the production of toxic oxygen products that diminish stimulated T-cell function [2527]