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Second, the antioxidant response element (ARE) acts as a pivotal modulator of Nrf2-driven SLC7A11 activation, with its relationship to Nrf2 occurring irrespective of p53 involvement (70)

In contrast to mitragynine, repeated administration of 7-hydroxymitragynine produces antinociceptive tolerance as well as cross-tolerance to morphines antinociceptive action and induces physical dependence 13

We detected that the depletion of GPX4 was more pronounced in SLC3A2 knockout cells compared to wild-type glioma cells, on the condition of ferroptosis inducer RSL-3 treatment

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