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Oxidative Stress Reduction & Antioxidant Effects Research indicates that Epithalon may play a role in mitigating oxidative damagea key mechanism in cellular aging

Whereas the the selective BET protein inhibitor apabetalone restored endothelial migration and tube formation in high-glucosetreated endothelial cells, suppressed the upregulation of the anti-angiogenic molecule thrombospondin-1 by preventing BRD4/H3K27ac-mediated chromatin activation and THBS1 transcription, preserved VEGFA signaling, and improved vascular perfusion and limb vascularization in diabetic models of endothelial dysfunction and hind limb ischemia [224]