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With no head-to-head data, comparing the two requires stitching together studies that differ in species, model, route, endpoint, and molecule a chain with several weak links

The specific collagen isoforms that give vein walls tensile strength and elasticity

On the mechanistic level [6], investigations have expanded beyond traditional core pathways such as OS, mitochondrial dysfunction, and neuroinflammation to encompass complex networks involving multi-organ system interactions like the gut-brain axis and spleen-brain axis