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Hormonal suppression drugs like birth control pills or Lupron are prescribed to shut down ovulation and induce estrogen deficiency

The GR inhibitor 2-Acetylamino-3-[4-(2-acetylamino-2-carboxy-ethylsulfanylthiocarbonylamino)phenylthiocarbamoylsulfanyl]propionic acid (2-AAPA) was prepared in DMSO, and then further diluted in MilliQ water and filter sterilised to produce a 1 mM stock solution

Given the female-specific origin of MenSCs, sex-based stratification should be considered an essential component of future clinical investigations

Activating Nrf2 not only scavenges ROS but also inhibits inflammation and promotes epithelial repair, providing an ideal target for treating DED (78)