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24 h after transfection, the medium was replenished and cells were cultured for 48 h

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This article originally appeared on Oklahoman: Peptides, while trendy, largely have been untested on humans

After three months of intragastric Dihexa administration (1.44 or 2.88 mg/kg), the APP/PS1 mice showed restored Morris water maze performance, increased neuronal cell counts and synaptophysin expression on Nissl staining, reduced microglial and astrocyte activation, decreased pro-inflammatory cytokines (IL-1, TNF-) and increased anti-inflammatory IL-10