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Its core pathogenesis involves the interplay of three key processes: immune dysregulation that is characterized by Treg dysfunction and B-cell hyperactivation, vascular endothelial injury and dysfunction, and abnormal fibroblast proliferation (226)

It is best understood as a possible adjunct to diet and exercise, not a standalone weight loss solution

Enhanced blood vessel formation could theoretically support tumor growth and spread

While toxicity is rare, excessive intake of certain B vitamins (particularly B or B) from multiple sources could increase the risk of side effects (like niacin flush or peripheral neuropathy)