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Research with NNMT blockers such as 5-amino-1MQ has demonstrated increased GLUT4 expression, greater glucose utilization, and enhanced metabolic activity

However, most previous silicosis studies overlooked significant changes in the biomechanical micro-environment in fibrotic lungs and the impact on cell function

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Importantly, this junction also represents the entry point into the pentose phosphate pathway (PPP), which shunts glucose away from energy production and instead generates NADPH, an essential cofactor required for glutathione synthesis and redox homeostasis