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Randomized and longitudinal studies have shown that folic acid and vitamin B12 supplementation modify DNA methylation profiles, both globally and at specific loci, consistent with enhanced methyl-group availability for DNMT-mediated reactions (104-106)

Additionally, TSA exerted anti-hypertrophic effects by suppressing intracellular calcium transients and the calcineurin/nuclear factor of activated T cells (Calcineurin/NFATc3) signaling pathway (163)