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While mammals have only one copy of the GPX4 gene, fish have two copies, GPX4a and GPX4b

The perhydroxyl radical (HOO) is another protonated form of O2 that starts the peroxidation of fatty acids (114)

This has led to the conclusion that under normal conditions, vitamin C helps safeguard the integrity of neurons (and therefore the brain), largely through neutralization of the free radicals of reactive oxygen species (ROS)

Indeed, recent findings correlate the effects of curcumin on the Nrf2 pathway with its properties as an autophagy inducer since autophagy activation appears to be essential in regulating the effects of the Nrf2 pathway [123]