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Proc Natl Acad Sci USA 90(15):72407244 Snchez-Pernaute R, Ferree A, Cooper O, Yu M, Brownell AL, Isacson O (2004) Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease

After 2 h of occlusion, the nylon wire was pulled out a certain length to allow reperfusion

Of note, the metabolic effects were attributed to butyrate serving as energy substrate and not butyrate acting as inhibitor of HDAC activity 93 , which has been reported to inhibit proliferation of colonic ISCs via Foxo3 116