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S1A), whereas the T94 2.61 I/M257 6.40 Y double mutant shows a main component at 478 nm and a smaller one at 378 nm, respectively, indicating the presence of protonated and unprotonated Schiff base-linked species (Fig

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These findings reveal increased chromatin accessibility surrounding the BCL-2 genomic locus in AR -/lo BCL-2 + subtype of CRPC and suggest that loss of AR expression and signaling might also promote BCL-2 expression via modulating the chromatin landscape