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Lipotoxicity caused by fatty acid accumulation and tubule-interstitial fibrosis linked to epithelial-to-mesenchymal transition are the hallmarks of diabetic nephropathy

To study this aspect, we measured the activity of the isolated Ab DGC domain upon mixing with an equal molar ratio of either of the two photocobilin proteins, isolated AdoCbl-bound forms of Ab Pcob or Sas Pcob (with and without bound BV) (Fig