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In the granulosa cells of patients with PCOS and in letrozole-induced rat models, the HIF-1/BNIP3 mediated mitophagy is suppressed, resulting in a decrease in the clearance capacity of damaged mitochondria and accumulation of ROS, thereby inducing mitochondrial dysfunction [71]

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Construction of yeast expression vectors The P1 coding sequences for PV1 wildtype strain Mahoney (Gene Bank: KU866422.1) and the Mahoney-SC7 mutant were optimized for yeast expression and synthesized by Genscript (Nanjing, China)

Only a few of the transplanted myoblasts survive when injected into dystrophic muscles and, if derived from a donor, are attacked by the bodys immune and inflammatory cells, causing rejection