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Complicating matters: While there are genes (such as GSTM1) that produce enzymes that facilitate the creation and recycling of GSH throughout the body, these genes are impaired in some people

Similarly, acetaminophen overdose leads to the formation of a toxic metabolite, N-acetyl-p-benzoquinone imine (NAPQI), which depletes glutathione and induces oxidative stress in the liver [57]