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Such approaches have been used to improve yields and purity of sulfur-based phytochemicals, allowing for downstream pharmacological testing with reduced batch-to-batch variability (Sadanov et al., 2025

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The histidine residue is essential for catalysis in HPII, and the side chain of valine residue makes the channel narrower to a diameter of about 3 that prevents any molecule larger than H 2 O and H 2 O 2 from gaining access to the active site