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Description

J Med Chem 2005;48:63266339

Inside the cells lactate remains in equilibrium with pyruvate due to very high activity of lactic dehydrogenase

LonialSWeissBMUsmaniSZSinghalSChariABahlisNJet al

As this enzyme catalyzes a reversible reaction between isocitrate and -ketoglutarate, the inverse reaction, so called the reductive carboxylation, could occur to maintain TCA cycle intermediates under mitochondria defects