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Interestingly, activation of AMPK in the hypothalamus promotes food intake behavior (231)

Nava Mesa, B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin, CNS Neurosci

Nature 441, 537541

In aged mice treated for 8 weeks at 10 mg/kg daily, sedentary mice showed approximately 40% greater grip strength than controls, and when combined with exercise, grip strength improved by approximately 60%