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This study was supported by the Guangdong Basic and Applied Basic Research Foundation (2024A1515011821), the Science and Technology Projects in Guangzhou (2025A03J4226), and the Longgang District Science and Technology Innovation Bureau Project (LGKCYLWS 2024-9)

The addition of glutathione into an in vitro solution may not be active as an oxidant in the absence of a system to generate the oxidized form of glutathione, which exists in different compartments in a living cell

Our prior investigations using bioinformatics analytics underscored a notable correlation between the cuproptosis phenotype and the prognosis of patients afflicted with HCC, insinuating a significant therapeutic potential of cuproptosis in oncology (161)