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Advanced materials (Deerfield Beach, Fla.) , 36 (21), e2311467

Leal H, Carvalhas-Almeida C, lvaro AR, Cavadas C (2024) Modeling hypothalamic pathophysiology in vitro for metabolic, circadian, and sleep disorders

Disease-associated mutants, in general, can produce hydrophobic patches in the protein due to local misfolding, which will result in aggregation 46,47,48