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[PubMed: 25624338] 20

These findings demonstrate that irisin confers neuroprotection in PD through multiple mechanisms, including the regulation of motor function, dopaminergic neuron survival, mitochondrial function, and neuroinflammation

Acta Neurol Scand 2000;102:143-149

For example, the chin area was always hyperactive and synkinetic, but showed a high degree of improvement even as the pharmacologic effect of BoNTA declined over time