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In addition, a plethora of non-motor symptoms (NMS) like sleep disorders, autonomic dysfunction, apathy and depression as well as cognitive dysfunction are major contributors to disease burden and poor quality of life [3,4,5]

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Epilepsy Behav 6(4):537542 Esvald EE, Tuvikene J, Sirp A, Patil S, Bramham CR, Timmusk T (2020) CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons