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Collectively, ferroptosis, as a form of oxidative cell death, is strongly context-dependent and requires an in-depth exploration of its underlying mechanisms [76]

DMF upregulates DNA hydroxymethylation We first determined whether DMF treatment mediates global or CBS locus-specific DNA methylation/hydroxymethylation (5mC/5hmC) modifications

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This anti-inflammatory response was mechanistically linked to the curcuminoids ability to inhibit the expression of toll-like receptors, toll-like receptor-2 (TLR-2) and TLR-4 at both the mRNA and protein levels, which are upstream regulators of NF-B and MAPK signaling pathways that drive cytokine production ( A synergistic approach combining natural products and targeted small molecules may offer a more effective strategy for addressing the multifactorial pathogenesis of NAFLD