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Coenzymes enhance the actions of enzymes, helping them to catalyze metabolic reactions

For Jerne this was, as he says, 'remarkable for two reasons: they are present in serum from a normal nonimmunized animal and their number increases enormously within a week after a single injection of a phage-antigen into this animal, i.e., before the serum obtains any appreciable phage-inactivating power' (Jerne, Sept 1955)

The discovery and development of Thienopyrimidines as inhibitors of Helicobacter pylori that act through inhibition of the respiratory complex I